Peptide reference · Synthetic pentapeptide (contains non-standard residues)
Ipamorelin COA check: molecular weight, formula and what to look for
Use these reference values to check the identity result on a Ipamorelin Certificate of Analysis. The theoretical average molecular weight of Ipamorelin is 711.85 Da and the monoisotopic mass is 711.386 Da.
Check a Ipamorelin COA nowIpamorelin reference data
| Name | Ipamorelin |
|---|---|
| Also known as | NNC 26-0161 |
| Type | Synthetic pentapeptide (contains non-standard residues) |
| Molecular formula | C38H49N9O5 |
| Average molecular weight | 711.85 g/mol (Da) |
| Monoisotopic mass | 711.3857 Da |
| Residues | 5 |
| Sequence | Aib-His-D-2Nal-D-Phe-Lys-NH₂ |
| Reference source | PubChem CID 9831659 (formula and mass cross-checked) |
Expected mass spectrometry ions
Electrospray (ESI) mass spectrometers measure mass-to-charge ratio (m/z), so a molecule can show up at several values depending on how many protons it picks up. If a Ipamorelin COA lists one of these m/z values instead of the neutral mass, that is still consistent with Ipamorelin.
| Ion | m/z (monoisotopic) | m/z (average) |
|---|---|---|
| [M+H]+ | 712.39 | 712.86 |
| [M+2H]2+ | 356.70 | 356.93 |
| [M+3H]3+ | 238.14 | 238.29 |
Calculated from the molecular formula using a proton mass of 1.00728 Da. High-resolution instruments report monoisotopic values. Lower-resolution or deconvoluted results are often closer to the average mass.
What a good Ipamorelin COA should show
- Identity by MS: a main mass within about ±1 Da of 711.85 (average) or 711.39 (monoisotopic), or one of the charge states above, with the spectrum image attached.
- Purity: ≥98% by HPLC (≥99% is excellent), with a chromatogram that shows retention time, peak area and a peak table.
- Traceability: the product name "Ipamorelin", a batch/lot number that matches your vial, a test date within the last 12 months, and the name of the testing lab.
- Independence: ideally a third-party lab with a report ID or QR code you can verify.
- Optional extras: net peptide content (actual mg per vial), endotoxin and heavy-metal results.
Ipamorelin-specific things to watch
Ipamorelin contains non-proteinogenic building blocks (Aib, D-2-naphthylalanine and D-phenylalanine) and a C-terminal amide. That means you cannot estimate its mass from a standard amino-acid table; the correct reference is about 711.9 Da average, 711.39 Da monoisotopic.
In positive-mode ESI, a strong [M+H]⁺ ion near 712.4 m/z and a [M+2H]²⁺ ion near 356.7 m/z are typical. If a COA lists 712 or 356, the checker will recognize these as charge states.
Ipamorelin is frequently sold blended with CJC-1295. A blend COA should show separate identity results for each component, not a single combined number.
Compounds with similar mass
If a COA's mass is off, compare it with these neighbors. A match to one of them can point to a mislabeled product.
- Selank: 751.87 Da (+40.02 Da)
- NAD+: 663.43 Da (-48.42 Da)
- SS-31 (Elamipretide): 639.79 Da (-72.06 Da)
Sources
- PubChem CID 9831659: Ipamorelin formula and reference mass.
- CIAAW: Standard atomic weights: Used to calculate average molecular weights.
- NIST CODATA: proton mass: Used to convert m/z charge states to neutral mass.
- PeptideCOACheck methodology: How the checker's thresholds work.
Last updated . Written and maintained under our editorial policy. Found an error? See corrections.
Frequently asked questions
What is the molecular weight of Ipamorelin?
The average molecular weight of Ipamorelin (C38H49N9O5) is 711.85 Da and its monoisotopic mass is 711.3857 Da, calculated from the molecular formula and cross-checked against PubChem CID 9831659.
What mass should a Ipamorelin COA show?
The mass spectrometry result should be within about ±1 Da of 711.85 Da (average) or 711.39 Da (monoisotopic), or show a matching charge-state ion such as 712.39 m/z.
What HPLC purity is good for Ipamorelin?
Most reputable suppliers target 98% or higher HPLC purity for Ipamorelin. 99% or higher is excellent. Below 95% is a warning sign.
How can I check a Ipamorelin COA for free?
Enter the COA values into the free checker on PeptideCOACheck. It compares the reported mass with the theoretical value for Ipamorelin, checks purity, test date, batch number and lab name, and runs a red-flag checklist. Everything stays in your browser.
For laboratory research use only. This page describes analytical chemistry data. It is not medical advice and makes no claim about effects in humans or animals.